| 英文摘要 |
There are no official regulation concerning the limit of drugs and heavy metals in artificial feeds of fish and shellfish worldwide . Therefore, the present project searched regulation regarding to the limit of drugs and heavy metals in fish and shellfish, and suggested that the production of artificial feeds should be controlled using HACCP scheme from row materials to manufacture in order to secure safety.
Residues of Furazolidone (FDZ) and its metabolite (AOZ) were measured in muscle after feeding groupers and eels with low concentration of FDZ (1.0ppb) in fish feeds. Residues of FDZ was only detectable with in 6hr in the muscle, livers, and serum of groupers and eels. In addition, the residues of AOZ were highest after feeding the fish for two to four weeks and slightly reduced in groupers fed for six to eight weeks. Howeres, the residues detected were all above the 1.0ppb limit. The results suggested that FDZ and AOZ should not be detected in fish feeds to avoid possible accumulation of AOZ in fish.
Eel meal-based diets (m.c.12%) were supplemented with 0.5mg Hg, 1.0mg Cd, 5.0mg Pb, 6.0mg As/Kg to feed groupers and eels for 79 days. There was no significant difference in the concertation the heavy metals tested in the edible tissues of groupers and eels. Howere, the accumulation of Cadmium in the fish livers was significant and the residual concentration was above EU Food Safety Limit (50-100 ng/g .w.w. ).
In conclusion, the residue of FDZ and AOZ in fish feeds is not suggested while the residue of the four heavy metals studied is not a food safety issue in fish feeds if only edible tissues (muscle) examined. |