| 英文摘要 |
The objectives of the research project are to establish the preparation technologies of micro/nanoparticles of Gracilaria polysaccharide, and Sargassum duplicatum polysaccharides or their oversulfated derivatives /chitosan. Additional objective is to evaluate the feasibilities of these micro/nanoparticle in reducing lipoproteins, dietetic food, and antioxidative or anticancer activity. First, to establish the preparation technologies of micro/nanoparticles of Gracilaria polysaccharide, chitosan, and Sargassum duplicatum polysaccharides or their oversulfated derivatives /chitosan. Then the reduction in body weight efficacy and safety tests will use male Wistar rats, by dietary feed for 8 weeks. The antioxidative properties and antiproliferating activity of micro/nanoparticles of Sargassum duplicatum polysaccharides or their oversulfated derivatives /chitosan will be measured by chemical and cancer cell lines assay respectively.If these micr- or nano-particles are safe and possess reduction in body weight and and antioxidative or anticancer activity. The integrating technic of micro- or nano-encapsulation with functional algal ingredient developed by this project will not only help improve the technology of utilizing domestic aquatic resources, but also help provide invaluable information to local industry for developing value-added aquatic functional food products. |